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KMID : 1156220180440010031
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Journal of Environmental Health Sciences
2018 Volume.44 No. 1 p.31 ~ p.43
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Novel Genotoxic Strategies for Efficiently Detect Chemicals’ Carcinogenicity
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Rim Kyung-Taek
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Abstract
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Objectives: Effective genetic toxicology and molecular biology research techniques and strategies that are highly correlated with the carcinogenic inhalation toxicity test and related research are required. The aim of this study was to maximize the utilization of chemical substances to prevent workers’ occupational diseases.
Methods: We surveyed the literature, domestic and international references, and the status of relevant domestic and foreign professional organizations. Expert advisory opinions were reflected, and experts were consulted by participating in domestic and overseas academic conferences.
Results: The current status of domestic and international genotoxic toxicity evaluation was examined through various documents from related organizations. Cell models for in vitro lung toxicology were investigated and summarized, and the human resourcesand performance results of genetic toxicity studies and pilot projects were compared and analyzed by holding an advisory meeting. We examined domestic and international genotoxicity guidelines and investigatednew test methods for the development of genotoxicity and carcinogenicity. Ultimately, we described long-term future predictions, including the implementation of our researchers’ recommendations and occupational genetic toxicology forecasts for future worker health protection.
Conclusions: This research project aims to establish current genetic toxicology and molecular biology research techniques and strategies that can maximize the linkage with the carcinogenic inhalation toxicity test and research in the future. We expanded the study of genetic toxicity and establish afoundation forgenetic toxicity in accordance with research trends in Korea and abroad.
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KEYWORD
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Development, genotoxic, strategies, chemicals, carcinogenicity
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